DIAGSAMPSI: Stata module for computing sample size for a single diagnostic test with a binary outcome

diagsampsi performs sample size calculations for sensitivity and specificity of a single diagnostic test with a binary outcome, according to Buderer (1996). The sample size computation depends on 3 quantities that the user needs to specify: (1) the expected sensitivity (specificity) of the new diagnostic test, (2) the prevalence of disease in the target population, and (3) a clinically acceptable width of the confidence interval for the estimates. Optionally, diagsampsi allows the user to choose the confidence level. In many cases, the user will want to compute a sample size that accounts for a different level of sensitivity and specificity (e.g. 80% and 60% for sensitivity and specificity, respectively). In this case, the larger of the two sample size estimates should be used to ensure the desired precision is preserved.

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